Epstein-Barr virus in selected cancer diseases

Authors

  • Marcin Koleśnik Department of Virology with SARS Laboratory, Medical University of Lublin
  • Anna Dworzańska Specialist Hospital in Radom
  • Małgorzata Polz-Dacewicz Department of Virology with SARS Laboratory, Medical University of Lublin

DOI:

https://doi.org/10.18388/pb.2020_364

Abstract

Viral infections contribute to many cancers worldwide and represent a significant percentage of deaths. Oncogenic viruses include the Epstein-Barr virus, which is the main cause of infectious mononucleosis and exhibits tropism towards B lymphocytes. Due to the presence of genes responsible for latency, it can contribute to many pathological conditions. Examples of this are high-fatal malignancies located in the stomach as well as in the head and neck. Moreover, this virus poses a serious threat to immunocompromised people, which is a significant problem nowadays due to the increasing number of patients undergoing immunosuppressive therapy. Particular attention in this case is lymphoproliferative disorders after transplantation, which are a malignant neoplasm associated with EBV infection. This review focuses on the role of the Epstein-Barr virus in selected cancers.

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Published

2021-01-05