Metalloproteases and their inhibitors: role in pathogenesis of selected examples

Authors

  • Anna Siemińska-Kuczer Department of Immunology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, UMCS, Lublin, Poland
  • Lidiia Vertyporokh Department of Immunology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, UMCS, Lublin, Poland
  • Mariola Andrejko Department of Immunology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, UMCS, Lublin, Poland
  • Iwona Wojda Department of Immunology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, UMCS, Lublin, Poland
  • Sylwia Stączek Department of Immunology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, UMCS, Lublin, Poland
  • Agnieszka Zdybicka-Barabas Department of Immunology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, UMCS, Lublin, Poland
  • Katarzyna Grygorczuk Department of Immunology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, UMCS, Lublin, Poland
  • Małgorzata Cytryńska Department of Immunology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, UMCS, Lublin, Poland

Abstract

Proteolytic enzymes and their inhibitors are crucial in host-pathogen interaction. Metalloproteases secreted by pathogenic microbes play an important role in destroying not only host tissues but also their immune proteins. Metalloproteinase inhibitors, in contrast, may serve as effective therapeutic agents, which is especially important because of the increasing number of microorganisms resistant to known antibiotics. The role of metalloproteases produced by the bacterium Pseudomonas aeruginosa in the colonization of the host organism is described. Attention has also been paid to the role of inhibitors of these enzymes in defense responses and underlined their potential role in inhibiting the development of infection.

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Published

2018-03-09

Issue

Vol. 63 No. 4 (2017): Special Issue ENZYMOS "Enzymes in Science and Industry"

Section

Articles

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