The role of NOD-like receptors (NLRs) in the pathogenesis of metabolic diseases

Abstract

NOD-like receptors (NLRs) are cytosolic proteins which involve in inflammatory processes and trigger programmed cell death. They are activatedby pathogenic and non-infectious agents. In human, this family of receptors consist of 23 different identified proteins. Some receptorsare forming multicenter complexes with procaspases and adaptive molecules ASC. Recently, attention has been paid to the important role ofNOD receptors not only in infections, cancers, autoimmune and neurodegenerative diseases (multiple sclerosis, Alzheimerâs disease, Parkinsonâs disease) but also in the pathogenesis of metabolic diseases, such as, obesity, non-alcoholic fatty liver disease (NAFLD) steatohepatitis (NASH), type 2 diabetes (T2DM), atherosclerosis, hypertension. In this review, we describe characteristic of the NLRs family and their participation in the pathogenesis of metabolic diseases.