The role of proprotein convertases in cancer diseases with particular focus on PACE4

Authors

  • Izabela Małuch Laboratory of Biopolymers Structural Research, Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Poland
  • Marta Makowska Laboratory of Biopolymers Structural Research, Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Poland
  • Marta Tomczykowska Laboratory of Biopolymers Structural Research, Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Poland
  • Aleksandra Walewska Laboratory of Peptide Chemistry, Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Poland
  • Emilia Sikorska Laboratory of Biopolymers Structural Research, Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Poland
  • Adam Prahl Laboratory of Peptide Chemistry, Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Poland

Abstract

Cancer is one of the most common cause of death nowadays. Thorough knowledge of the mechanisms of tumorigenesis and invasiveness of tumor cells is crucial for the development of molecular targeted therapies, which are believed to be future treatment of this type of diseases. Proteolytic enzymes are one of the factors involved in the development of cancer cells, very often used as markers of tumor progression. In this paper we describe the role of enzymes termed proprotein convertases (PCs) in pathogenesis and progress of cancer diseases. Furthermore, we indicate potential directions for the development of therapeutic strategies designed based on PCs inhibitors.

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Cover 3 2017

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Published

2017-09-30

Issue

Vol. 63 No. 3 (2017)

Section

Articles

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