Fungal secondary metabolites as a source of bioactive compounds: a modern approach to their acquisition and analysis

Authors

  • Piotr Michałowski Instytut Technologii i Inżynierii Chemicznej, Politechnika Poznańska, Poznań oraz Pracownia Chemii Medycznej, Centrum Biologii Chemicznej, Instytut Chemii Bioorganicznej Polskiej Akademii Nauk, Poznań
  • Katarzyna Rynarzewska Instytut Technologii i Inżynierii Chemicznej, Politechnika Poznańska, Poznań
  • Dagmara Nowicka Instytut Technologii i Inżynierii Chemicznej, Politechnika Poznańska, Poznań
  • Olimpia Gawrońska Wydział Informatyki i Telekomunikacji, Politechnika Poznańska, Poznań
  • Katarzyna Bielicka-Daszkiewicz Instytut Technologii i Inżynierii Chemicznej, Politechnika Poznańska, Poznań

DOI:

https://doi.org/10.18388/2dqryt92

Abstract

Secondary metabolites, which are natural products of fungi, perform key biological functions and have applications in medicine. The production of these compounds is subject to the control of clusters of biosynthetic genes located within the genome. It has been observed that these genes can become dormant under standard culture conditions. The advent of modern genetic and epigenetic methodologies has rendered the activation of these elements possible, thus facilitating the identification of novel bioactive compounds. The present article delineates classes of metabolites, the mechanisms of their biosynthesis, and current research strategies, combining knowledge from biology, genetics, and biotechnology.

 

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Published

2026-01-09

Issue

Vol. 72 No. 1 (2026)

Section

Articles

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Copyright (c) 2026 Piotr Michałowski, Katarzyna Rynarzewska, Dagmara Nowicka, Olimpia Gawrońska, Katarzyna Bielicka-Daszkiewicz

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