The double-stranded microRNA precursor

Authors

  • Elisabetta Scarfiello Regensburg Center for Biochemistry (RCB), Laboratory for RNA Biology, University of Regensburg, Regensburg, Germany
  • Julian Eichlinger Regensburg Center for Biochemistry (RCB), Laboratory for RNA Biology, University of Regensburg, Regensburg, Germany
  • Gunter Meister Regensburg Center for Biochemistry (RCB), Laboratory for RNA Biology, University of Regensburg, Regensburg, Germany

DOI:

https://doi.org/10.18388/pb.2021_522

Abstract

MicroRNAs (miRNAs) are generated from stem-loop-structured double-stranded RNA precursors by the consecutive action of the two RNase III-type endoribonuclease Drosha and Dicer. However, such structures are very common on cellular transcripts and specific features have evolved that guide and regulate processing of stem-loop-structured hairpins into mature and functional miRNAs. These features include sequence motifs and local RNA structures but also trans-acting factors such as RNA binding proteins. The menu of features required for miRNA biogenesis is summarized in this review.

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Published

2024-05-23

Issue

Vol. 70 No. 1 (2024): 70 LAT BADAŃ PODWÓJNEJ SPIRALI KWASÓW NUKLEINOWYCH Numer Specjalny poświęcony pamięci profesorów: Ronalda Hancocka i Mieczysława Chorążego, pod redakcją profesor Joanny Rzeszowskiej-Wolny

Section

Articles

License

Copyright (c) 2024 Elisabetta Scarfiello, Julian Eichlinger, Gunter Meister

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