The role of physicochemical processes in the formation of the 3D genome and compartmentalization of the cell nucleus

Authors

  • S Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russian Federation

DOI:

https://doi.org/10.18388/pb.2021_512

Abstract

The review analyzes the role of physicochemical processes in the formation of the function-dependent architecture of the cell nucleus, built on the platform of a folded genome. The main attention is paid to various forms of the phase separation process, primarily the processes of liquid-liquid phase separation and polymer-polymer phase separation. The role of these processes in the formation of chromatin compartments and maintenance of three-dimensional genome architecture is discussed in detail. The relationship between genome activity and the creation of functional compartments in the cell nucleus is also analyzed.

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Published

2024-05-23