The role of transcriptional regulators in the control of gene expression in prokaryotes based on Pseudomonas aeruginosa model bacterium

Abstract

Bacteria from Pseudomonas aeruginosa species are often found in environments such as water or soil, but are also known to be opportunistic pathogens of humans and animals. Characteristic feature of these bacteria is their high ability to survive in very different ecological niches. Such capability of adaptation to changing conditions is derived from the extended regulatory networks and the use of a rich repertoire of genome-encoded proteins, pathways and adaptive mechanisms.

Transcriptional regulators are key components of gene expression regulation responding to environmental signals by turning on or off specific pathways. Studies on transcription factos using transcriptomic and genomic methods provide knowledge about the mechanisms of their action, regulated genes and processes enabling understanding complex regulatory networks controlling cell life.

The aim of this work is to present the results of research on the regulation of bacterial transcription visualized on the basis of P. aeruginosa pathogen and the characteristics of the mechanism of regulation of genes involved in the virulence of this bacterium.