In health and disease – microRNA in skeletal muscles function

Authors

  • Karolina Romańczuk Department of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1 St, 02-096 Warsaw, Poland
  • Bartosz Mierzejewski Department of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1 St, 02-096 Warsaw, Poland https://orcid.org/0000-0001-7517-349X
  • Zuzanna Michalska Department of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1 St, 02-096 Warsaw, Poland
  • Anita Florkowska Department of Cytology, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1 St, 02-096 Warsaw, Poland https://orcid.org/0000-0002-2536-9520

DOI:

https://doi.org/10.18388/pb.2021_419

Abstract

MicroRNAs (miRNAs), although do not encode proteins, they are involved in many biological processes. Here we focus on their role in skeletal muscle development and function. In health, they play an important role during skeletal muscle regeneration by regulating satellite
cells quiescence, activation, proliferation, differentiation into myoblasts, and finally formation of myotubes. Moreover, miRNAs play a role in muscles disease development. For this reason, they can be used as disease biomarkers or potential therapeutic targets. Moreover, physical activity also influences the changes in miRNA expression. Certain types of exercises, their duration, and intensity differently impact the expression of many miRNAs.

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Published

2022-01-14

Issue

Vol. 67 No. 4 (2021): Numer specjalny poświęcony biologii rozwoju zwierząt

Section

Articles

License

Copyright (c) 2022 Advances in Biochemistry

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