The key role of AMP-activated protein kinase (AMPK) in aging process
Abstract
Aging is one of the most extensively studied biological process and yet still some of its aspects remain elusive. It appears that AMP â activated protein kinase (AMPK) plays an important role in many processes of aging, but this fact is often neglected in the studies on aging. This work summarizes the information about AMPK participation in the aging process. AMPK participation in the regulation of aging was indicated in the mechanisms dependent on: caloric restriction, mTOR, p53, sirtuins, autophagy, inflammation and the effects caused by polyphenols.
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