The age-related alerations in the enteric nervous system and their impact on peristalsis of the gastrointestinal tract

Authors

  • Agata Szymaszkiewicz Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland
  • Kamil Szymaszkiewicz Department of Pharmacology and Toxicology, Faculty of Medicine, Medical University of Lodz
  • Jakub Fichna Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland
  • Marta Zielińska Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland

DOI:

https://doi.org/10.18388/pb.2021_367

Abstract

Constipation occurs more often in old patients, because the intestinal peristalsis decreases with aging. Constipation is caused due to impaired
motility of the intestines, intestinal barrier damage and the imbalance between the absorption and secretion of water and electrolytes, as well
as disturbed production and release of intestinal hormones, infiltration of the gastrointestinal tract with immune cells, excessive production of
pro-inflammatory cytokines and the alterations in the functions of enteric nervous system.

In this review we will discuss the most important issues associated with the process of aging of the digestive tract, focusing on the enteric nervous system.

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Published

2021-02-12

Issue

Vol. 67 No. 1 (2021)

Section

Articles

License

Copyright (c) 2021 Advances in Biochemistry

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