Oncogenic viruses and cancer

Authors

  • Alicja Warowicka Department of Animal Physiology and Developmental Biology, Adam Mickiewicz University in Poznań, Poland
  • Robert Nawrot Molecular Virology Research Unit, Adam Mickiewicz University in Poznań, Poland
  • Justyna Broniarczyk Molecular Virology Research Unit, Adam Mickiewicz University in Poznań, Poland
  • Martyna Węglewska Molecular Virology Research Unit, Adam Mickiewicz University in Poznań, Poland
  • Anna Goździcka-Józefiak Molecular Virology Research Unit, Adam Mickiewicz University in Poznań, Poland

DOI:

https://doi.org/10.18388/pb.2020_360

Abstract

Oncogenic viruses (oncoviruses) are implicated in approximately 12% of all human cancers. Currently, the viruses known to cause human cancer are: Hepatitis B and C viruses (HBV and HCV), Human Papillomaviruses (HPV), Merkel Cell Polyomavirus (MCV), Human Herpesvirus-8 (HHV-8), Epstein-Barr Virus (EBV) and Human T-cell lymphotropic virus-1 (HTLV-1). However, oncoviruses are not complete carcinogens, need additional factors andisplay different roles in transformation. Oncoviruses can directly disrupt important regulatory cell genes by inserting virus genom into the DNA of the host cell. They also contain their own genes that damage the regulation of the cell. Some viruses have v-onc that cause disregulation of cellular processes and can lead to cancerous growth.

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Published

2021-01-05

Issue

Vol. 66 No. 4 (2020): Special Issue "Viral Threats of the 21st Century"

Section

Articles

License

Copyright (c) 2021 Advances in Biochemistry

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