Ketogenic diet â mechanism of action and perspectives for the use in the therapy: data from clinical studies

Authors

  • Natalia Pondel Laboratorium Badań Molekularnych, Instytut Badawczo – Rozwojowy Fizjoterapii i Nauk o Zdrowiu, Akademia Wychowania Fizycznego im. J. Kukuczki w Katowicach, ul. Mikołowska 72a, 40-065 Katowice
  • Daniela Liśkiewicz Laboratorium Badań Molekularnych, Instytut Badawczo – Rozwojowy Fizjoterapii i Nauk o Zdrowiu, Akademia Wychowania Fizycznego im. J. Kukuczki w Katowicach
  • Arkadiusz Liśkiewicz Katedra i Zakład Fizjologii, Wydział Nauk Medycznych w Katowicach, Śląski Uniwersytet Medyczny w Katowicach, ul. Medyków 12, 40-752 Katowice

DOI:

https://doi.org/10.18388/pb.2020_342

Abstract

Ketogenic diet is a high fat and very low-carbohydrate nutritional approach that induces  increased production of ketone bodies, which serve as an alternative to glucose energetic substrates. Since almost a century ketogenic diet has been used in the therapy of refractory epilepsy, especially in children. Because of the pleiotropic effect of ketogenic diet on physiology,  including inflammation, oxidative stress, energy balance and signaling pathways, in recent years scientists have been intensively exploring the use of it in the treatment of other diseases. In the present article current clinical studies regarding the possibility of using the ketogenic diet in the treatment of obesity, diabetes, neurological disorders and cancer has been reviewed alongside with potential mechanisms responsible for the therapeutic effect of ketogenic diet in these diseases. The metabolic processes engaged in nutritional ketosis and practicals aspects of ketogenic dieting have been also discussed

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Published

2020-11-02 — Updated on 2020-12-13

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