Oxidative stress in etiopathogenesis of inflammatory bowel diseases

Authors

  • Michal Kloska Department of Medicine, Lehigh Valley Health Network, Allentown, Pennsylvania, USA
  • Dorota Mańkowska-Wierzbicka Department of Gastroenterology, Dietetic Nutrition and Internal Diseases, Poznan University of Medical Sciences
  • Magdalena Człapka – Matyasik Faculty of Food Science and Nutrition, Department of Human Nutrition and Hygiene, Poznan University of Life Sciences
  • Agnieszka Dobrowolska Department of Gastroenterology, Dietetic Nutrition and Internal Diseases, Poznan University of Medical Sciences
  • Marian Grzymisławski Department of Gastroenterology, Dietetic Nutrition and Internal Diseases, Poznan University of Medical Sciences

DOI:

https://doi.org/10.18388/pb.2020_324

Abstract

Inflammatory bowel diseases are a group of chronic diseases of the digestive tract of unknown origin. The etiology of IBD is multifactorial and involves interaction between genetic, environmental and immunological factors with oxidative stress being an inherent part of any one of them. Therefore, the redox equilibrium is crucial to maintain cell homeostasis in the gastrointestinal (GI) tract, which is constantly exposed to large numbers of commensal and pathological bacteria. Distortion of this homeostasis and increase in oxidative stress leads to the propagation of inflammation, mucosal injury in the GI tract and is associated with the development and exacerbation of IBD.

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Published

2020-06-27

Issue

Vol. 66 No. 2 (2020)

Section

Articles

License

Copyright (c) 2020 Advances in Biochemistry

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