From mitochondrial large amplitude swelling to the permeability transition – a short historic overview

Authors

  • Lech Wojtczak Department of Biochemistry, Nencki Institute of Experimental Biology PAS, Warsaw, Poland
  • Mariusz R. Więckowski Department of Biochemistry, Nencki Institute of Experimental Biology PAS, Warsaw, Poland

DOI:

https://doi.org/10.18388/pb.2016_29

Abstract

An outline of studies on the mitochondrial large conductance permeability pore is presented starting from the early observations in the 1950s on the large amplitude mitochondrial swelling, through the concept of the permeability transition and various theories on the structure of the related permeability transition pore, up to its present identification as a part of mitochondrial (F1 FO) ATPase/ATP synthase.

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Published

2016-11-18

Issue

Vol. 62 No. 3 (2016): Alexander Wlodawer 70th Birthday

Section

Articles

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