Strategies in Crohnâs disease treatment â "step-up" vs. "top-down"

Authors

  • Marta Piotrowska Department of Biochemistry, Faculty of Medicine, Medical University of Lodz
  • Julia Krajewska Department of Biochemistry, Faculty of Medicine, Medical University of Lodz
  • Jakub Fichna Department of Biochemistry, Faculty of Medicine, Medical University of Lodz
  • Kinga Majchrzak Department of Biochemistry, Faculty of Medicine, Medical University of Lodz

DOI:

https://doi.org/10.18388/pb.2019_288

Abstract

Inflammatory bowel diseases (IBD) are chronic conditions that lead to serious complications and act to the detriment of quality of patientsâ lives. Etiology of IBD has not been precisely determined but it is assumed that IBD is caused by genetic, immune and environmental factors. The main target in current IBD treatment is the induction and maintenance of remission. The most common strategy in IBD therapy is called „step-up” that is based on gradual introduction of stronger drugs. However, the latest research shows that „top down” strategy is more promising and can change the natural course of the disease. The aim of this article is to discuss both strategies and compare their effectiveness

Downloads

Download data is not yet available.

Downloads

Published

2020-01-04

Issue

Vol. 65 No. 4 (2019)

Section

Articles

License

All journal contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made, ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original. There are no additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Copyright for all published papers © stays with the authors.

Copyright for the journal: © Polish Biochemical Society.