Transcription factor ChREBP â the coordinator of carbohydrate and lipid metabolism

Authors

  • Joanna Krawczak Zakład Regulacji Metabolizmu, Instytut Biochemii, Wydział Biologii, Uniwersytet Warszawski
  • Aleksandra Owczarek Department of Metabolic Regulation, Institute of Biochemistry, Faculty of Biology, University of Warsaw
  • Katarzyna Winiarska Department of Metabolic Regulation, Institute of Biochemistry, Faculty of Biology, University of Warsaw

DOI:

https://doi.org/10.18388/pb.2019_282

Abstract

Transcription factor ChREBP, in complex with MLX, binds to carbohydrate-response element (ChoRE) located in the promoters of genes related to glycolysis, gluconeogenesis, pentosephosphate pathway and lipogenesis, activating their transcription following stimulation with glucose, insulin-independently. In this article the mechanisms of ChREBP regulation and ChREBP functions under both physiological and pathophysiological conditions are described in detail. The possible use of ChREBP activity modulation as a therapeutic tool, e.g. in case of nonalcoholic fatty liver disease, diabetes type 2 and cancers, is also discussed.

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Published

2020-01-09

Issue

Vol. 66 No. 1 (2020)

Section

Articles

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