Characteristic of AMP and the effects of chemical modifications on the modulation of their antimicrobial properties

Authors

  • Marta Makowska Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Poland
  • Adam Prahl Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Poland
  • Izabela Małuch Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Poland

DOI:

https://doi.org/10.18388/pb.2019_280

Abstract

Antibiotics have revolutionized the pharmacology market but their âgolden area” passed away. The urgent need to develop new medicins with the mechanism of action different than those already used is constantly growing because of the drug-resistance of pathogenic microorganisms. The observed increasing resistance of microbes motivates scientists to design innovative strategies based on the natural peptides that exhibit antimicrobial activity. In this article we present general characterization of antimicrobial peptides and effects of chemical modifications on the modulation of their antimicrobial properties.

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Published

2019-11-21

Issue

Vol. 65 No. 4 (2019)

Section

Articles

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