Cancer stem cells in renal carcinoma

Authors

  • Łukasz Szymanski Zakład Ochrony Mikrofalowej, Wojskowy Instytut Higieny i Epidemiologii im. gen. Karola Kaczkowskiego, ul. Kozielska 4, 00-001 Warszawa
  • Igor Helbrecht 1 – Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw, Poland; 2 – Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw, Warsaw, Poland
  • Michał Fiedorowicz
  • Damian Matak 1 – Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw; 2 – School of Molecular Medicine, Medical University of Warsaw, Warsaw
  • Ewa Bartnik 1 - Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw, Warsaw; 2 - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw
  • Paweł Golik 1 - Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw, Warsaw; 2 - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw
  • Cezary Szczylik Klinika Onkologii, Europejskie Centrum Zdrowia, Otwock
  • Anna M. Czarnecka Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw

DOI:

https://doi.org/10.18388/pb.2019_250

Abstract

Cancers account for 85% of renal tumors. In Poland renal cancer is diagnosed in almost four thousands patients every year and two thousands of them dies. The most common subtype of renal cancer is clear cell renal cell carcinoma (ccRCC), which accounts for 80-90% of all renal cancer cases. ccRCC is resistant to chemo- and radiotherapy. More and more data suggest that tumor growth is a result of proliferation and differentiation of a small population of cells called cancer stem cells (CSC). CSCs are responsible for tumor progression and for the resistance to chemo- and radiotherapy. This publication covers the role the CSCs and their origin in renal cell carcinoma, with particular emphasis on clear cell subtype.

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Published

2019-06-06

Issue

Vol. 65 No. 2 (2019)

Section

Articles

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