Changes of mitochondrial dynamics as a response to mitochondrial stress in models of sporadic Parkinsonâs disease

Abstract

Sporadic Parkinsonâs disease (sPD) is one of the most common neurodegenerative diseases. Degeneration of dopaminergic neurons in the substantia nigra and the stratium, are the hallmarks of the disease. Numerous studies have shown that dysfunctions of mitochondrial respiratory chain complex I and oxidative stress are associated with sPD development. Mitochondria are dynamic organelles, constantly undergoing processes of fusion and fission. Shape of mitochondrial network is modified in accordance to cellular needs and external stimuli. Growing number of evidence show the presence of disturbances of mitochondrial dynamics in sPD. The aim of this article is to summarize recent data concerning role of mitochondrial dynamics in sPD pathogenesis.