Cyclophilins â proteins with many functions
DOI:
https://doi.org/10.18388/pb.2018_104Abstract
Cyclophilins together with FK-506-binding proteins and parvulins, belong to a group of proteins that have peptidyl-prolyl cis-trans isomerase activity. They also belong to proteins that are collectively known as immunophilins. Cyclophilins are found in all cells of all organisms studied, in both prokaryotes and eukaryotes. The first member of the cyclophilins to be identified in mammals, cyclophilin A, is the major cellular target for the immunosuppressive drug cyclosporin A. This review discusses recently available data about proteins with cyclophilin domain (CBD). Recent studies have implicated a diverse array of additional cellular functions for cyclophilins, including roles as chaperones and in cell signalling as well as in several human diseases.
Downloads
Downloads
Published
Issue
Section
License
All journal contents are distributed under the Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) license. Everybody may use the content following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made, ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original. There are no additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Copyright for all published papers © stays with the authors.
Copyright for the journal: © Polish Biochemical Society.
