Transgenic mice as models to study the influence of polyunsaturated fatty acids on metabolism

Authors

  • Kamila Stepanow Department of Genomics and Biodiversity, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 36A Postępu St., Jastrzebiec, 05-552 Magdalenka, Poland
  • Magdalena Ogłuszka Department of Genomics and Biodiversity, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 36A Postępu St., Jastrzebiec, 05-552 Magdalenka, Poland
  • Adam Lepczyński Department of Physiology, Cytobiology and Proteomics, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology Szczecin, 29 Klemensa Janickiego St., 71-270 Szczecin, Poland
  • Ewa Poławska Department of Genomics and Biodiversity, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 36A Postępu St., Jastrzebiec, 05-552 Magdalenka, Poland
  • Mariusz Pierzchała Department of Genomics and Biodiversity, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 36A Postępu St., Jastrzebiec, 05-552 Magdalenka, Poland

DOI:

https://doi.org/10.18388/pb.2018_101

Abstract

The mouse is a popular animal model employed for studying metabolic alterations. The generation of fat-1 transgenic mice by Professor Jing
X. Kang and collaborators has revolutionised the omega-3 research. Fat-1 mice are able to convert omega-6 fatty acids to omega-3 fatty acids
due to gene fat-1 from Caenorhabditis elegans that encodes an omega-3 fatty acids desaturase. This mice model can endogenously synthesize
omega-3 PUFA without ALA intake and the balancing quantity and quality of various confounding factors of different diets. Next, novel
transgenic mice â âOmega mice” with the expression of the fat-1 and fat-2 transgenes were created to produce both omega-6 and omega-3
PUFA from a diet containing saturated fat or carbohydrates with essential fatty acids deficiency. Both transgenic mice are utilities for studying
molecular mechanisms of omega-3 fatty acids and their metabolites in tumorigenesis and inflammatory disorders.

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Published

2018-11-22

Issue

Vol. 64 No. 1 (2018)

Section

Articles

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