The role of physicochemical processes in the formation of the 3D genome and compartmentalization of the cell nucleus

Autor

  • Sergey V. Razin Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russian Federation

DOI:

https://doi.org/10.18388/pb.2021_512

Abstrakt

The review analyzes the role of physicochemical processes in the formation of the function-dependent architecture of the cell nucleus, built on the platform of a folded genome. The main attention is paid to various forms of the phase separation process, primarily the processes of liquid-liquid phase separation and polymer-polymer phase separation. The role of these processes in the formation of chromatin compartments and maintenance of three-dimensional genome architecture is discussed in detail. The relationship between genome activity and the creation of functional compartments in the cell nucleus is also analyzed.

Pobrania

Statystyki pobrań niedostępne.

Pobrania

Opublikowane

2024-01-15

Numer

Dział

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